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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
20
Human Site:
S369
Identified Species:
29.33
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S369
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S369
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
Y438
L
I
S
K
L
L
R
Y
Q
P
L
E
R
L
P
Dog
Lupus familis
XP_853397
405
45606
S370
R
L
L
K
H
N
P
S
Q
R
P
T
L
K
D
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S360
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
Rat
Rattus norvegicus
P59241
397
44856
S362
R
L
L
K
H
N
S
S
Q
R
L
T
L
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
R270
L
K
H
N
P
Y
Q
R
L
T
L
K
E
V
L
Chicken
Gallus gallus
XP_425725
409
46456
G369
Y
P
L
F
V
T
E
G
A
R
D
L
I
S
K
Frog
Xenopus laevis
Q91819
408
46443
P375
S
K
L
L
K
H
N
P
N
H
R
L
P
L
K
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
S287
I
S
K
L
L
R
H
S
P
S
M
R
L
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
T295
K
E
S
K
G
R
I
T
L
V
D
V
M
T
H
Honey Bee
Apis mellifera
XP_395732
327
37711
S294
E
G
A
K
D
L
I
S
K
L
L
I
V
D
P
Nematode Worm
Caenorhab. elegans
O01427
305
34731
E272
P
K
A
R
C
T
L
E
Q
V
K
E
H
Y
W
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
N245
L
L
Q
H
N
P
A
N
R
L
P
L
E
Q
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
Q249
S
A
K
D
L
I
S
Q
M
L
V
K
E
S
T
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
K334
D
A
Q
D
L
I
L
K
L
L
K
Y
D
P
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
13.3
80
N.A.
73.3
73.3
N.A.
0
13.3
6.6
13.3
N.A.
6.6
13.3
6.6
13.3
P-Site Similarity:
100
100
20
93.3
N.A.
73.3
73.3
N.A.
0
33.3
26.6
13.3
N.A.
33.3
33.3
13.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
13
0
0
0
13
0
7
0
0
0
0
13
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
13
7
0
0
0
0
0
13
0
7
7
7
% D
% Glu:
7
7
0
0
0
0
7
7
0
0
0
13
19
0
25
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
7
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
7
7
32
7
7
0
0
7
0
0
7
0
7
% H
% Ile:
7
7
0
0
0
13
13
0
0
0
0
7
7
0
0
% I
% Lys:
7
19
13
50
7
0
0
7
7
0
13
13
0
7
19
% K
% Leu:
19
38
44
13
25
13
13
0
19
25
32
19
38
13
13
% L
% Met:
0
0
0
0
0
0
0
0
7
0
7
13
7
0
0
% M
% Asn:
0
0
0
7
7
32
7
7
7
0
0
0
0
0
0
% N
% Pro:
7
7
0
0
7
7
19
7
7
7
25
0
7
13
13
% P
% Gln:
0
0
13
0
0
0
7
7
44
0
0
0
0
7
0
% Q
% Arg:
32
0
0
7
0
13
7
7
7
38
7
7
7
13
0
% R
% Ser:
13
7
13
0
0
0
13
44
0
7
0
0
0
13
0
% S
% Thr:
0
0
0
0
0
13
0
7
0
7
0
19
0
7
7
% T
% Val:
0
0
0
0
7
0
0
0
0
13
7
7
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
7
0
0
0
0
7
0
7
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _